Novel Small-Molecule Antifungal Agents
- Group II Introns are found in fungi but not in mammals.
- A high-throughput screen for inhibitors of identified 16 reproducible hits of Group II intron splicing
- Most potent inhibitor has MIC of 2 µg/ml vs Candida parapsilosis (comparable with Amphotericin B)
- non toxic in mammalian cell culture model