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Novel Small-Molecule Antifungal Agents

Novel Small-Molecule Antifungal Agents

  • Group II Introns are found in fungi but not in mammals.
  • A high-throughput screen for inhibitors of identified 16 reproducible hits of Group II intron splicing
  • Most potent inhibitor has MIC of 2 µg/ml vs Candida parapsilosis (comparable with Amphotericin B)
  • non toxic in mammalian cell culture model