Clotting Disorders
Human Serum Enzyme Overcomes Multiple Ultra-Rare Congenital Clotting Disorders
- OCR 5775 is a therapeutic protein designed to overcome clotting defects:
- it is resident to the circulatory system
- has been purified and crystallized to ultra-high resolution
- its activity is known to be triggered only at sites of platelet degranulation triggered under physiological conditions (i.e. response to vascular damage)
- As shown in the figure, weak aggregation is seen in in the absence of OCR 5775 (blue curve) in a patient with a poorly characterized platelet storage disease. The addition of 50 nanomolar of (black curve) normalizes the clotting profile.
- This technology may also have utility in a critical care situation such as the Emergency Department for acute bleeding episodes (e.g., NSAID toxicity), first response, or military situations.