Compounds and Compositions for Disrupting Programmed Ribosomal Frameshifting
Compounds and Compositions for Disrupting Programmed Ribosomal Frameshifting
Programmed ribosomal frameshifting is a prevalent and critical feature among RNA viruses
Dr. Junjie Guo’s lab at Yale has developed a platform to rapidly identify chemical modifiers of ribosomal frameshifting and has identified compounds that either enhance or suppress ribosomal frameshifting of SARS-CoV-2 and other beta coronaviruses.
Frameshift inhibition significantly inhibited SARS-CoV-2 replication in Vero E6 cells.
