Ex Vivo Organ Preservation – Brain, etc.

Novel Device & Coupled Perfusate – Biomechanicomimetic platform (A)
- Perfusate with a-cellular Hb-based gas exchange, cellular preservation, anti-inflammatory and antineurotoxic formulation
- Multiple organ compatibilities (B/C)
- Minimal organ coupling (B/F)
Ex Vivo Validation-Porcine Brain
- 4 hours post-mortem repair and preservation
- Architecture
  - Global Micro CTA (D)
  - Doppler Ultrasound (E)
- Cerebral Metabolism (F)
- Neurotransmission restoration
Potential Uses
- Ex vivo drug testing (PK/PD, BBB, ADME-T)
- Ex vivo surgical procedures
- Transplant organ preservation, reclamation, and assessment
Innovators: Sestan Lab
Pending Patents and Publication