THERAPEUTICS

Arya Mani, MD, FACC, FAHA, Robert W Berliner Professor of Internal Medicine (Cardiology) and Professor of Genetics

Generation of a humanized antibody to prevent thoracic and abdominal aortic aneurysm dissection and rupture

Berna Sozen, PhD, Assistant Professor of Genetics

Implantoid Platform for Infertility Medicine 

Carrie Lucas, PhD, Associate Professor of Immunobiology

Resetting the immune system for autoimmune and inflammatory diseases

Christian Schlieker, PhD, Professor of Molecular Biophysics and Biochemistry, Professor of Cell Biology

Small molecule and enzymatic approaches to revert aberrant phase transitions in neurological disorders 

Christine Ko, MD, Professor of Dermatology and Pathology

Harnessing p53beta as a medical treatment of skin cancer

Christopher Bunick, MD, PhD, Associate Professor of Dermatology
Novel treatment for hypertrophic and keloidal scarring 

Chuan-Ju Liu, PhD, (Stephen Waxman, MD, PhD), Charles W. Ohse Professor of Orthopaedics & Rehabilitation

ChondroNEXT: Preventing progression of joint degeneration in osteoarthritis 

Demetrios Braddock, MD, PhD, Associate Professor of Pathology

Targeting genetically associated childhood and adult obesity

Dianqing (Dan) Wu, PhD, Gladys Phillips Crofoot Professor of Pharmacology

Innovative Preventative Treatment for Delayed Graft Function in Kidney Transplantation: First in Class, Lead Candidate Ready for IND Studies, Ferroptosis Inhibitor

Ho-Joon Lee, PhD, Research Scientist in Genetics

EDDIT: Early Drug Discovery for Targeted Protein Degradation

Jaime Grutzendler, MD, Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Neuroscience
Brain Endothelium-Targeted Therapy for Cerebral Cavernous Malformations 

James Hansen, MD, MS, Associate Professor of Therapeutic Radiology

First-in-class antibody targeting NETosis

Janghoo Lim, PhD, Associate Professor of Genetics and Neuroscience

Innovative approach to treat ALS using a novel small molecule target

Jeffrey Ishizuka, MD, DPhil, Assistant Professor

curIOS Therapeutics: mRNA therapies targeting the driver antigens in virus-associated cancers

Jose L. Gomez-Villalobos, MD, MS, Associate Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine)

Targeting Non-Tuberculous Mycobacteria with AI-Designed Antimicrobial Peptides

Markus Müschen, MD, PhD, Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology 

A new class of selective GSK3B-inhibitors for refractory lymphoid malignancies

Martin Schwartz, PhD, Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Biomedical Engineering and of Cell Biology

Therapeutic targeting of protocadherin gamma A9 (Pcdhga9)

Ranjit Bindra , MD, PhD (W. Mark Saltzman, PhD), Harvey and Kate Cushing Professor of Therapeutic Radiology and Professor of Pathology

B3 Therapeutics: Bypassing the blood brain barrier for the treatment of primary CNS tumors and brain metastases

Richard Kibbey, MD, PhD, Ensign Professor of Medicine (Endocrinology and Metabolism), and Professor of Molecular and Cellular Physiology

Small Molecule Incretin Hormone Amplifier for the Treatment of Obesity and Diabetes

Seth Herzon, PhD, Milton Harris ’29 Ph.D. Professor of Chemistry 

DNA Self-Activating Warheads (SAWs)

Steven Tang, PhD, Assistant Professor

Towards small-molecule contraceptives targeting sperm-egg fusion

W. Mark Saltzman, PhD, Goizueta Foundation Professor of Biomedical Engineering and Professor of Cellular and Molecular Physiology and of Chemical Engineering

Evershield: Long-acting, biodegradable implants for local, sustained drug release

Xiaolei Su, PhD, Associate Professor of Cell Biology

CAR-mast Cell Therapy for Solid Tumors

Yingqun Huang, MD, PhD, Professor, Obstetrics, Gynecology & Reproductive Sciences

Inflammation & Immunology Breakthrough: Molecular glues for the selective elimination of pathogenic macrophages