Treating Alzheimer’s Disease by blocking TGF-β signaling

• Blocking the transforming growth factor-β (TGF-β) pathway in peripheral macrophages can significantly clear up βamyloid plaques in the brain.
• These results provide the basis for a novel therapeutic intervention for Alzheimer’s disease by blocking the TGF-β-Smad2/3 signaling pathway in peripheral macrophages.
• Blockade of TGF-β works peripherally without the need to permeate the bloodbrain barrier to enter the brain.
• Intellectual Property: U.S. Patent 9,095,126