Dr. Pober was born in Brooklyn, New York in 1949 and grew up in the New York City metropolitan area. He attended Haverford College, graduating summa cum laude in 1971 with high honors in Biology, Chemistry and History. He was admitted to Yale’s Medical Scientist Training Program, receiving his MD and his PhD in Molecular Biophysics and Biochemistry with Prof. Lubert Stryer in 1977. He completed his first year of pathology residency at Yale-New Haven Hospital in 1978, was a post-doctoral fellow with Prof. Jack Strominger in the Department of Biochemistry at Harvard University from 1978 through 1980, and completed pathology training at Brigham and Women’s Hospital in 1981. He worked as an attending Pathologist at Brigham and Women’s Hospital from 1981-1991, serving as an Assistant Professor and then Associate Professor of Pathology at Harvard Medical School during the same period.

He returned to Yale Medical School in 1991 as a Professor of Pathology and Immunobiology, and also became a Professor of Dermatology in 1998. Dr. Pober was named the Director of the Molecular Cardiobiology Program at the Boyer Center for Molecular Medicine in 1991 and founded the Vascular Biology and Transplantation (VBT) Program, which succeeded Molecular Cardiobiology, in 1999. In 2007, he stepped down as the director of the VBT program, becoming Professor and Vice-Chair of the Department of Immunobiology for the Section of Human and Translational Immunology. He was named Ensign Professor of Immunobiology in 2011 and Bayer Professor of Translational Medicine in 2012. Dr. Pober has been honored as a Searle Scholar, an Established Investigator of the American Heart Association and a MERIT awardee of the National Heart, Lung and Blood Institute. He received the Warner Lambert-Parke Davis award in 1988 and the Rous Whipple Award in 2011 from the American Society of Investigative Pathology, the Earl Benditt award from the North American Vascular Biology Organization in 2014 and the Basic Science Established Investigator Award from the American Society of Transplantation in 2018. He has served as an Editor of Immunity and Co-Editor-in Chief of Laboratory Investigation, leading immunology and pathology journals, respectively. He also has served as President of the North American Vascular Biology Organization. He is co-founder and co-director of the Joint Yale-Cambridge University Biomedical Research Program, is a visiting fellow in the Dept. of Medicine at the University of Cambridge, and was elected a Fellow Commoner of Trinity Hall, University of Cambridge in 2012. .

Dr. Pober’s research involves understanding the functions of blood vessels and vascular cells in human inflammatory and immune responses and, reciprocally, how inflammation and immunity affect vascular health and function. He is particularly interested in how insights from experiments with human cells and tissues and with humanized mice can be used to improve organ replacement therapy, to improve tissue engineering and to regenerate injured tissues.