3E10 is a cellpenetrating mAb that transports a donor DNA for gene editing into cells and tissues in vivo

• Advantages:
  • No need for DNA cutting or binding agent
  • Patient treatment by simple IV administration of simple mixture of geMab and donor DNA
• Established manufacturing processes for both components
• The approach has no sequence limitations to reagent design
• Therapeutic applications. Gene editing to correct mutations causing genetic disorders: sickle cell disease, thalassemia, cystic fibrosis, lysosome storage diseases
• Lead Innovator: Peter Glazer, Ph.D.
• IP status: pending "COMPOSITIONS AND METHODS FOR ENHANCING DONOR OLIGONUCLEOTIDE BASED GENE EDITING"