Implantation of biomaterials and devices into soft tissues leads to the development of the foreign body response (FBR), which can interfere with implant function and eventually lead to failure – currently there are no therapeutic options.
Yale researchers have identified that the acute inflammatory response to biomaterials can be limited by inhibition of inflammasome-related pathways.
Aspirin reduces significantly reduces the FBR in response to silicone implants, as shown in figures (*†P ≤ 0.05)
Advantages:
Improve the function of biomaterials
Reduce the need to replace biomaterials and devices
Reduce side effects from inflammation related to biomaterials
