Human iPSC-based Tissued Engineered Vascular Graft
Human iPSC-based Tissued Engineered Vascular Graft
Current Tissue engineered vascular grafts (TEVGs) developed from primary cells have limited expandability and donor-donor functional variation of the primary cells.
Dr. Yibing Qyang’s lab has developed a method to generate TEVGs using vascular smooth muscle cells derived from human induced pluripotent stem cells (hiPSC-VSMCs).
hiPSC-TEVGs have mechanical strength comparable to that of saphenous veins employed clinically as vascular grafts, and maintained mechanical function following rat implantation.
