Dr. Andrew Goodman’s research shows that the gut microbes were responsible for producing 20- 80% of the circulating toxic metabolites derived from 3 drugs.
Combining gut commensal genetics with gnotobiotics, they measured brivudine drug metabolism across tissues in mice that vary in a single microbiome-encoded enzyme
Built a pharmacokinetic model that quantitatively predicts microbiome contributions to systemic drug and metabolite exposure, as a function of bioavailability, host and microbial drug-metabolizing activity, drug and metabolite absorption, and intestinal transit kinetics.
Publication: Science. 2019 Feb 8;363(6427). Epub 2019 Feb 7.
