Nanoparticles for Controlled Delivery of Nucleic Acids

• Numerous formulations for biodegradable nanoparticles for controlled nucleic acid delivery:
  • Achieve high loading and encapsulation
  • Retain chemical and functional integrity of cargo
• Applications:
  • Highly efficient non-viral vectors for DNA/gene delivery;
  • siRNA/mRNA/PNA/oligo delivery for RNA silencing;
  • Gene transfection of stem cells;
  • Treatment of genetic diseases and cancers, combined gene and drug delivery
• Lead Innovator: W. Mark Saltzman, Ph.D.
• Pending and Issued Patents: 9,272,043, PCT/US2015/030169, 14/988,538, others