Precise engineering of protein materials and biologics
- Enable manufacturing of genetically encoded materials (GEMs) for applications in medicine, electronics, environmental sustainability, fabrics, aerospace, and beyond
- Established broad proprietary platform for programmable GEMsproduction
- Advancing proof-of-concept products for technologyvalidation
- Extended protein half-life in an animal model using a GEM that enables site-specific modification with fatty acids
- Created tunable, self-assembling GEM-nanoparticles for applications in drug delivery and vaccines
- Preliminary in vivo data demonstrates lack of immunogenicity to synthetic amino acids used in GEMs
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Team: Farren Isaacs, PhD, Michael Jewett, PhD, Natalie Ma, PhD, Barry Schweitzer, PhD
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Select Publications: Lajoie et al. Science. 2013;342(6156):357; Amiram et al. Nat. Biotechnol.
2015;33: 272; Orelle et al. Nature. 2015;524(7563):119; Martin et al. Nat. Comm. 2018; 9(1):1203