Perimenopause affects 1.3 billion women worldwide yet remains dramatically under-diagnosed. Estraflow will be a non-invasive wearable that continuously monitors estradiol in interstitial skin fluid using an aptamer-based electrochemical biosensor. Unlike episodic blood tests, Estraflow will capture real-time hormonal fluctuations, enabling personalized tracking of perimenopause onset and progression. Our AI platform will correlate estradiol patterns with symptoms, empowering women and clinicians with actionable data to guide treatment decisions.