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Circulating autocatalytic anti-DNA antibody 3e10

• Background: A key feature of the tumor microenvironment, compared to healthy tissue, is the presence of a comparatively larger amount of extracellular DNA from actively dividing, apoptotic or necrotic tumor cells.
• Circulating anti-DNA autoantibody 3e10 penetrates cell nuclei. When it is conjugated to the surface of nanoparticles, it targets the nanoparticles to the extracellular DNA in the tumor environment.
• The conjugate works in an autocatalytic manner that increases in efficiency with time and treatment.
• Innovators: James Hansen and Jiangbing Zhou
• IP status: Provisional patent application filed
• Reference: Chen et al. (2016) Oncotarget