Convection-enhanced Delivery of Drug-Loaded Nanoparticles to the Brain Tumors

• Biodegradable nanoparticles (NPs) have been optimized to penetrate through tumor tissue when delivered by convection-enhanced delivery (CED).
• Delivery of drug-loaded enhanced NPs by CED outperforms treatment with “standard” NPs or drug alone.
• Could also be used to deliver therapeutics to the brain for other indications besides oncology.
• References: Zhou et al., 2012 Cancer; 2013 PNAS; Ediriwickremaet et al., 2014 Biomaterials; Gaudin et al., 2016 Biomaterials; Saucier-Sawyer et al., 2016 J Control Release.
• Patents Applications: 20150118311; 20140371712
• Lead Innovator: Mark Saltzman, Ph.D.