Antibody Engineering - ADCs

Selenocysteine (Sec) Method
- Therapeutic Utility
  - ADC & Rx proteins with novel properties & compositions
  - Rapid Purification via Sec
  - Efficiencies of incorporation of Sec/U: 70-100%
Phosphoserine (Sep) Method
- Dehydroalanine
- Target for chemical modification of proteins to yield the natural protein modifications
- Amenable to “Click Chemistry” modification