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Reduction of IL-17A with an Inhibitor of miR466l-3p Binding to IL-17A mRNA
Reduction of IL-17A with an Inhibitor of miR466l-3p Binding to IL-17A mRNA
- The microRNA miR466l-3p stabilizes IL-17A mRNA thereby increasing IL-17A levels.
- IL-17A plays a pathogenic role in multiple inflammatory diseases (e.g., MS, IBD, Psoriasis).
- A nucleotide has been developed that selectively blocks this miR466l-3P site on the IL-17A mRNA, and reduces IL-17A levels.
- In vivo proof of concept of this therapeutic approach has been demonstrated in two mouse models of MS.
- A provisional patent application has been filed.
