Novel Pleuromutilin Antibiotics
Total Synthesis and Synthetic Route for Novel Antibiotics
- About the Pleuromutilins
- Bacterial protein synthesis inhibitor
- Pleuromutilins approved/in the clinic
- Approved (retapalmulin; Altabax®) for topical use (impetigo)
- Phase 3: lefamulin (oral) various bacterial indications
- Current production Pleuromutilins
- >3000 semisynthetic derivatives prepared modulated at C14
- Little other exploration due to synthetic difficulties
- Future Production/Novel Pleuromutilins
- Total synthesis at high efficiency
- Ability to modulate ring size, introduce atomic substitutions, conduct deep SAR
- Commercially viable routes; high overall yield, short convergent synthesis
- Complete stereocontrol
- Total synthesis facilitates novel chemistry
- OCR7106 IP Status:
- Total synthesis at high efficiency
- Publications (Science, etc.)
- Multiple patents filed (available under CDA)