Accidental poisoning is an increasingly common cause of intensive care unit care. Aminitin poisoning is highly mortal with no available treatments beyond supportive care, in part because, in general, poisoning physiology is not well understood. To address this, we performed an in vivo screen of poisoning responses and discovered distinct immune responses to distinct poison classes. Using amanitin, we identified a unique receptor tyrosine kinase (RTK) involved in the immunopathology induced by the amanitin poison class and found that therapeutic blockade of this RTK rescues animals from death. This application seeks to generate and validate novel composition of matter to enhance our intellectual property position.