The survival of organisms depends on efficient tissue repair due to continuous exposure to microtrauma, and wear and tear throughout life. When an injury occurs, a series of events unfold to stop bleeding, repair blood vessels, and remodel tissues, ultimately restoring normal function. We discovered novel mechanisms that regulate thrombosis and vascular recanalization and introduced  thromboangioplasticity, a multicellular process at the juncture of hemostasis and repair. We identified two interrelated pathways that modulate this mechanism to prevent hemorrhage and accelerate vascular recanalization. We propose to develop therapies for conditions with microvascular occlusion, including stroke, pulmonary embolism, and tissue injury.