Tumor Activated Permeability (TAP) Therapy is a small molecule platform targeting drug delivery to all solid tumors via a universal property of solid tumors: Acidity.

pH affects cell permeability of weakly-ionic drugs

• Tumor acidity shown to be far stronger than previously accepted, via improved pH probes
• Acidity universal in solid tumors, 95% of cancers
• The TAP platform uses a medicinal chemistry strategy to control drug distribution, targeting tumors and preventing uptake in healthy tissues
• Library of novel weak acid moieties with pKA tuned to titrate between tumor and healthy pH
• Improves the drug’s therapeutic index
• Applicable to most small molecule drugs
• IP remains unpublished, provisional patents filed