A short hairpin RNA, alone or in combination with anti-PD1 therapy, activates Rig-I and stimulates immune response

• Stem Loop RNA 14 (SLR14) induces interferon production as a RIG-I agonist.
• Efficacy demonstrated in mouse in vivo tumor models.
• Combination augments efficacy of anti PD-1 therapy.
• Has abscopal and memory effects.

IP status: US62/743369, US2016/0046942, WO2014159990

Innovators: Anna Pyle, Ph.D., Akiko Iwasaki, Ph.D.