Immunogenic Epitopes as Targets for Universal Cancer Vaccines

• Unlike other vaccine-based technologies, OCR 5120 is not cancer-type specific, but a “panvaccine” antigen opportunity
• The human immune system can respond to OCR5120 and identify the specific immunogenic epitopes derived from the OCR5120 antigen (see figure) as a matter of surveillance rather than response.
• OCR5120 target:
  • is important in self-renewal and maintenance of pluripotency in embryonic stem cells
  • is not cancer-type specific
  • is a “pan-vaccine” antigen
• Applications: 
  • Universal target for a general cancer vaccine
  • OCR5120-specific cellular preventive therapy for preventing cancer-like sides effects arising from stem cellbased therapies