We have developed an innovative foam-based surgical antiseptic that overcomes the limitations of current liquid antiseptics like ChloraPrep and DuraPrep, which depend heavily on user technique and risk spreading bacteria across the surgical site. Our self-expanding foam guarantees uniform coverage, even in skin folds and on vertical surfaces, while maintaining the rapid antimicrobial efficacy and drying time of leading products. The foam's application does not require brushing, thereby minimizing operator variability, enhancing patient safety, and preventing pooling and uneven drying.