POLARIS is an AI-powered clinical decision support tool to prevent recurrent stroke. POLARIS can empower hospitals with automated, guideline-recommended, and timely AI-driven secondary stroke prevention therapeutic and diagnostic recommendations to frontline care providers within the electronic health record that are individualized to each specific patient hospitalized with an acute ischemic stroke. This can lead to lower rates of recurrent stroke and neurologic deterioration as well as reduced rates of hospital readmissions.